DuPont has expanded its bioprocessing portfolio with the launch of DuPont AmberChrom TQ1 chromatography resin for the purification of oligonucleotides and peptides in support of a wide-range of biopharma applications.

“The introduction of DuPont AmberChrom TQ1 chromatography resin supports the accelerated development and commercialization of oligonucleotide and peptide therapeutics,” said Shane Kendra, Global Bioprocessing Market Leader for DuPont Water Solutions. “In addition to expanding our capabilities, this new anion exchange chromatography resin offers exceptional performance, setting a new standard in this product class and creating new opportunities in high growth therapy areas.”

The new agarose-based chromatography resin offers increased loading capacity, higher throughput, and requires less pressure than comparable competing products within the same class. These characteristics make DuPont AmberChrom TQ1 chromatography resin an excellent choice for high resolution separations and polishing, offering high purity fractions in biomolecule purifications and the separation of closely-related impurities from target molecules. Its low-pressure build-up, combined with high-yield and purity for peptides and both DMT-Off and DMT-On oligonucleotides, makes the resin suitable for use in benchtop and large-scale commercial purifications.

“Further expansion of DuPont’s bioprocessing portfolio reflects our commitment to providing a comprehensive one-stop shop for the purification and polishing of oligonucleotides and peptides,” said Kendra. “Our technical teams and scientists are continually collaborating with customers to design efficient bioprocessing solutions for every stage of the drug development journey.”

DuPont AmberChrom TQ1 chromatography resin can be used in combination with existing AmberChrom XT and CG chromatography resins to purify various oligonucleotide feeds, or for the crude purification of peptide feeds in preparation for reverse phase chromatography.