Purolite, a global manufacturer of resin-based chromatography separation, purification and extraction technologies, announced the commercialization of two novel next-generation chromatography resins:

1. Praesto Jetted A50 HipH, is the world's first protein A alkaline stable resin based on a 50μm uniform agarose bead, designed to address the purification of pH sensitive antibodies or other Fc containing proteins. With 40 years of resin bead expertise, Purolite has combined 'Jetting' technology - an innovative process that produces uniform size agarose beads with a very narrow particle size distribution - together with a new, Protein A ligand, NGL-Impact A Hi pH, from Repligen Corporation.

2. Praesto Jetted (dT)18-DVB is a new 50μm styrene jetted based resin designed to purify mRNA constructs used in vaccine and gene therapy applications. Customer results demonstrate that this new resin outperforms both other resin based dT solutions and monolith based dT technology also.

Chris Major, General Manager for Purolite stated, "We are delighted with the launch of these two new affinity resins and I am proud that we have transformed the future of affinity chromatography by addressing two key requirements within the industry. It's great to work once again with Repligen and develop the world's first protein A resin that provides milder elution conditions, in the region of pH 5, whilst still providing high capacity close to 60 g/l. Results show up to a 70% increase in yield when compared to conventional protein A resins, since aggregation is minimized. Studies also have shown improved host cell protein clearance, which reduces the burden on future downstream steps." He continued, "The launch of our dT resin was a strategic move by the company to expand our offering and resin knowledge into the rapidly evolving field of mRNA therapies critical in vaccines and gene therapy applications."