Canadian-based compound specialist OTAVA (OTAVAchemicals) and German frontrunner cheminformatics firm BioSolveIT announce the release of a new, multibillion-sized pool of on-demand chemicals, available for therapeutic R&D. CHEMriya — alluding to Mriya, the Ukrainian word for dream— is a chemical space comprising 11 billion tangible screening compounds that are not present in any other commercial chemical catalog.

This vast pool of opportunities can be explored with BioSolveIT's unique virtual screening platform infiniSee. With utmost precision, infiniSee finds those compounds that are similar to a query molecule, scanning billions of possibilities within seconds. Traditional search technologies, by comparison, are prohibitively slow for such highly relevant applications. "We are very excited to be at the forefront of this exciting new field — the creation and delivery of compounds mined from huge chemical spaces. BioSolveIT has a globally unique technology that permits our clients, researchers around the globe, to find those precious needles in giga-size haystacks", Dr. Yaroslav Bilokin, Executive Director of OTAVA says.

The pharma research industry is in desperate need of novel chemical matter. In the past, high-throughput screening (HTS) demanded millions of molecules to be synthesized. Now, the invention of rapid and reliable on-demand synthesis marks a paradigm shift: Companies favor cherry-picking over mass production and testing; they now explore from billions of compounds — yet they only synthesize hundreds of the most promising candidates. This is a giant leap for pharmaceutical research, accelerating its productivity while reducing costs. Early success stories have reported that a gain of "two times faster" and "ten times cheaper" could be achieved. Dr. Christian Lemmen, CEO of BioSolveIT, explains: "OTAVA's tangible compound concept and our way of computing are a perfect match: Harnessing the combinatorial explosion, based on their impressive synthetic repertoire in CHEMriya, leads the way to a novel and highly efficient way of early drug discovery."

While routinely designing and synthesizing novel molecules at this scale was unthinkable only a few years ago, now, billions of novel molecules have become not only tangible but also affordable.